the monthly percentage of deaths involving illegally made fentanyl (IMF) with xylazine detected increased from 3% in January 2019 to 11% in June 2022. In a recent study from CDC’s State Unintentional Drug Overdose Reporting System ( SUDORS), among 20 states and Washington D.C. 5 In Philadelphia, Pennsylvania, xylazine was found in 31% of heroin and/or fentanyl overdose deaths in 2019. 4 In samples from eight syringe service programs in Maryland tested between 20, xylazine was found in almost 80% of drug samples that contained opioids. One study from 10 US cities showed xylazine was involved in less than 1% of drug overdose deaths in 2015 and in nearly 7% in 2020. 3 Studies from specific areas found similar increases. The presence of xylazine in drugs tested in labs increased in every region of the United States from 2020-2021, with the largest increase in the South. On July 11, 2023, the White House released a National Response Plan to address the emerging threat of fentanyl mixed with xylazine. 2ĭue to its impact on the opioid crisis, fentanyl mixed (adulterated) with xylazine has been declared an emerging threat by the White House’s Office of National Drug Control Policy. 1 Xylazine-which is not approved for use in people-can be life-threatening and is especially dangerous when combined with opioids like fentanyl. A tranquilizer called xylazine is increasingly being found in the US illegal drug supply and linked to overdose deaths.
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